SGK1 OVEREXPRESSION Detail (hg38) (SGK1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr6:134,490,384-134,639,196 View the variant detail on this assembly version. |
| hg38 | chr6:134,169,246-134,318,058 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer | Alpelisib | D |
Predictive
|
Supports
|
Resistance | Somatic | 5 | 27451907 | Detail |
| breast cancer | Alpelisib | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 27451907 | Detail |
| breast cancer | Alpelisib,SGK1-Inh | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 27451907 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| SGK1 mRNA expression was elevated in five breast cancer cell lines which were resistant to PI3Kalpha... | CIViC Evidence | Detail |
| A group of 18 breast cancer patients were treated with PI3Kalpha inhibitor alpelisib (NVP-BYL719) pl... | CIViC Evidence | Detail |
| The alpelisib (PI3Kalpha inhibitor) resistant breast cancer cell line HCC1954 was treated with alpel... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- SGK1
- Genome
- hg38
- Position
- chr6:134,169,246-134,318,058
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000367858.5
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/693
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